Philosophical assumptions on suffering

Aristotle claims that if you are suffering terrible misfortune, you cannot truly be considered happy or flourishing.  However, there are many examples from current and past history, religious traditions, and fiction of people that might seem to contradict this claim (for example, in the Beatitudes (Matt. 5:3-12, Luke 6:20-23) Jesus describes people that seem to be suffering in various ways and calls them “blessed”; some translations say “happy”).   Leaving aside any religious assumptions and considering this from a strictly philosophical perspective, do you think that it’s possible for people to be happy or flourishing even if they are suffering terrible misfortune?  Provide at least one example to illustrate your answer, and refer to the readings and media to support your view.